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The primary function of Class 5 Integrating Indicators is to correlate with the physical performance of a biological indicator. Class 5 indicators are designed to provide a broader context by integrating multiple variables during sterilization processes. They reflect the effectiveness of the sterilization cycle and are sensitive to changes in the environment, such as temperature and humidity, that can influence the biological indicator's performance.

By correlating with biological indicators, Class 5 Integrating Indicators ensure that the sterilization process is not only effective but also reliable by integrating the conditions needed for successful sterilization. This is vital in healthcare settings, where the safety and efficacy of sterilization are paramount to patient care and infection control. The other options focus on specific aspects of sterilization or cleaning processes, which are not the primary function of Class 5 Integrating Indicators.