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Proper loading of the sterilizer is critical to ensure effective sterilization of medical instruments and equipment. The correct answer emphasizes the necessity of balanced loads and ensuring that items do not touch the walls of the sterilization chamber.

Balanced loads are essential because they allow for even steam distribution around the instruments, which is crucial for effective sterilization. If the load is too heavy on one side or if items are packed too tightly, steam may not circulate properly, leading to potential areas that remain unsterilized. Furthermore, ensuring that instruments do not touch the chamber walls is important because direct contact with the walls can interfere with the sterilization process. The chamber walls may cool down faster than the contents, leading to uneven heating and inadequate sterilization of those items in contact with the walls.

This focus on balanced loads and proper spacing helps prevent changes in temperature and pressure that could compromise the sterilization cycle's effectiveness, ensuring all items are adequately sterilized.